FOXO4-DRI
Senolytic — targeted clearance of senescent cells
Where This Comes From
Full traceability from synthesis to your vial. No blind sourcing.
cGMP Synthesis
[cGMP Manufacturer — to be disclosed]
cGMP FacilityIndependent Testing
Analytika ISO Labs Inc. (ISO 17025 Accredited)
ISO 17025 LabBatch Released
Tested January 6, 2025 — all parameters pass.
COA PublishedWhat's in the Vial
Add solvent slowly; FOXO4-DRI may take 3–5 minutes to dissolve at room temperature due to its D-retro-inverso structure. Gentle warming to 37 °C can aid dissolution. Refrigerate at 2–8 °C; use within 14 days of reconstitution.
General Protocol Ranges
These are published research ranges — not a prescription. Your physician finalizes your protocol.
FOXO4-DRI is a highly experimental compound. Preclinical mouse studies used 1–5 mg/kg IP or IV on alternating days for 3 doses. Human dosing has no established protocol — this is a physician-determined research application only.
Why Physician Oversight?
SourcePeptideCo does not dispense research-grade peptides without licensed physician oversight. This isn't a formality — these compounds interact with individual biochemistry in ways that require clinical judgment.
Our process: you submit a consultation intake, a coordinator matches you with a licensed physician in your state within one business day, and the physician designs a protocol appropriate to your research goals and health profile.
No physician sign-off, no order. That's the standard we hold to.
Request Consultation for FOXO4-DRI →Frequently Asked Questions
Senolytics are compounds that selectively induce apoptosis in senescent cells — cells that have stopped dividing but remain metabolically active, secreting pro-inflammatory factors (the SASP). Senescent cell accumulation is one of the primary hallmarks of aging. Clearing them is a central strategy in longevity research.
DRI (D-retro-inverso) peptides use D-amino acids in reversed sequence, making them protease-resistant. Natural peptides are rapidly degraded in vivo; the DRI modification gives FOXO4-DRI much longer circulation stability without altering its target interaction, which depends on structural mimicry rather than enzymatic activity.
Lyophilized peptide powder: store at −20 °C for long-term (up to 24 months) or at 4 °C for up to 6 months. Once reconstituted: refrigerate at 2–8 °C, use within the timeframe specified on your product (typically 14–30 days). Avoid repeated freeze-thaw cycles.
Our lyophilized peptides carry a 24-month expiry from manufacture date as printed on the batch label. Each COA confirms the exact lot date and expiry. Once reconstituted, shelf life drops significantly — see the reconstitution notes for your specific compound.
SourcePeptideCo operates through a licensed physician network. Peptide research compounds can interact with medications, contraindicate with certain conditions, and require clinical judgment for correct dosing. We don't sell without physician oversight — not as a formality, but because the oversight is part of the value.
A Certificate of Analysis (COA) documents the test results for a specific production batch. It certifies identity (the peptide is what we say it is), purity (by HPLC-UV), molecular mass (by LC-MS), endotoxin levels, and sterility. Every batch is tested by an independent ISO 17025-accredited laboratory.